ML204 hydrochloride,5465-86-1(free base)

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抑制剂描述：

产品名称：ML204 hydrochloride

产品别名：见爱必信官网

英文别名：ML204 hydrochloride

靶点：TRP Channel

CAS：5465-86-1(free base)

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM.

溶解性：H2O : ≥ 30 mg/mL (114.16 mM)

体外研究：

ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise. ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters. ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels.

体内研究：The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.

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