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保存条件 :Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
库存 :99
供应商 :爱必信(上海)生物科技有限公司
CAS号 :838818-26-1
规格 :100mg/50mg/10mg/5mg
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抑制剂描述: 产品名称:wiki4 产品别名:见爱必信官网 英文别名:wiki4 靶点:PARP CAS:838818-26-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling. 溶解性:DMSO 7 mg/mL warmed (13.42 mM) 体外研究: WIKI4 inhibitsWnt/ß-catenin signaling in all tested cell lines, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma and hESCs. WIKI4 increases the steady-state abundance of theWnt/ß-catenin inhibitory protein, AXIN1 by inhibiting tankyrase activity, and thus preventing the ubiquitylation and degradation of AXIN proteins. 体内研究: 产品信息订购:
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