DASA-58,1203494-49-8

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抑制剂描述：

产品名称：DASA-58

产品别名：见爱必信官网

英文别名：DASA-58

靶点：PKM2

CAS：1203494-49-8

纯度：>98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：DASA-58 is a highly specific small molecule PKM2 activator. DASA-58 inhibits LPS-induced Hif-1a and IL-1b, as well as the expression of a range of other Hif-1a-dependent genes.

溶解性：DMSO: ≥ 35 mg/mL

体外研究：

DASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells.

体内研究：DASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice.

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