产品详情
文献和实验
相关推荐
保存条件 :Store at -20℃
库存 :99
供应商 :爱必信(上海)生物科技有限公司
CAS号 :1164462-05-8
规格 :1mg
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
试剂描述: 产品名称:TG4-155 产品别名: CAS号:1164462-05-8 英文别名:TG4-155 分子量:394.5 分子式:C23H26N2O4 纯度:≥98% 外观:见爱必信官网 保存方法:Store at -20℃ 描述:Prostaglandin E2 (PGE2) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection.1,2,3 TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels.4,5 It blocks the induced expression of inflammatory markers in microglial cells treated with the selective EP2 agonist butaprost (Item No. 13740) alone or with LPS and IFNγ.4,6 TG4-155 significantly reduces neurodegeneration in a mouse model of status epilepticus, induced by pilocarpine (Item No. 14487).4 It inhibits proliferation, invasion, and inflammatory cytokine expression in cancer cells treated with butaprost.5 应用: 产品信息订购:
absin,您身边的科研百宝箱 |
爱必信(上海)生物科技有限公司
品牌商实名认证
钻石会员
入驻年限:12年