4Alpha-佛波-13-乙酸-12-豆蔻酸酯,63597-44-4

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试剂描述：

产品名称：4Alpha-佛波-13-乙酸-12-豆蔻酸酯

产品别名：

CAS号：63597-44-4

英文别名：4Alpha-佛波-13-乙酸-12-豆蔻酸酯

分子量：616.8

分子式：C₃₆H₅₆O₈

纯度：>99%

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保存方法：Store at -20° C

描述：

4α-Phorbol 12-myristate 13-acetate (4α-PMA) is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA , a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

应用：A phorbol ester analog, binds to TRPV4, increases PGHS-2 mRNA in murine keratinocytes

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