Topoisomerase IIα-IN-4

价格：询价

品牌：MedChemExpress(MCE) 品牌认证

货号：HY-151453

产品详情

Topoisomerase IIα-IN-4

CAS No. : 2860554-26-1

MCE 国际站：Topoisomerase IIα-IN-4

产品活性：Topoisomerase IIα-IN-4 (F2) 是非嵌入性、ATP 竞争性的 人 DNA 拓扑异构酶 II 抑制剂，对 TopoIIα 和 TopoIIβ 的 IC₅₀ 值分别为 3.8 和 10.1 μM。Topoisomerase IIα-IN-4 在 HepG2 细胞中具有诱导凋亡和细胞周期阻滞的作用。Topoisomerase IIα-IN-4 对人类癌细胞株具有较强的抗肿瘤活性，可用于癌症的研究。

研究领域：Cell Cycle/DNA Damage | Apoptosis

作用靶点：Topoisomerase | Apoptosis

In Vitro: Topoisomerase IIα-IN-4 (0-50 μM; 72 h) shows antiproliferative activities against cancer cells. Topoisomerase IIα-IN-4 shows high inhibitory activity and subtypeselectivity against TopoIIα and β with IC₅₀s of 3.8 and 10.1 μM, respectively.Topoisomerase IIα-IN-4 (0.3 μM; 4 h) is a non-intercalative TopoIIα catalytic inhibitor.Topoisomerase IIα-IN-4 (0.5-1 μM; 48 h) induces cell apoptosis.Topoisomerase IIα-IN-4 (0.5-1 μM; 24 h) induces cell-cycle arrest.

In Vivo: Topoisomerase IIα-IN-4 (500 mg/kg; p.o. twice at the first day) shows no acute toxicity in vivo.