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BMT-090605 hydrochloride

CAS No. : 2231664-45-0

MCE 国际站：BMT-090605 hydrochloride

产品活性：BMT-090605 hydrochloride 是一种有效的选择性连接蛋白-2 相关激酶 1 (AAK1) 抑制剂，IC₅₀ 值为 0.6 nM。BMT-090605 hydrochloride 显示抗伤害活性。BMT-090605 hydrochloride 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 GAK，IC₅₀ 值分别为 45 nM 和 60 nM。BMT-090605 hydrochloride 可用于神经性疼痛的研究。

研究领域：Cell Cycle/DNA Damage  |  Neuronal Signaling

作用靶点：Cyclin G-associated Kinase (GAK)  |  AAK1

In Vitro: BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC₅₀ of 0.63 nM.
BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀ values of 45 nM and 60 nM, respectively.

In Vivo: BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord.

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