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适应物种 :Human
保质期 :12个月
级别 :科研用
库存 :大量供应
供应商 :无锡东林科技
标记物 :APC,FITC,PE
保存条件 :Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
形态 :liquid
规格 :20T/100T/200T
This product is a FCM antibody cocktail made up of APC Anti-Human CD3 Antibody [Clone: OKT3] (Mouse IgG2a, κ), FITC Anti-Human CD4 Antibody [Clone: RPA-T4] (Mouse IgG1, κ) and PE Anti-Human CD8a Antibody [Clone: OKT-8] (Mouse IgG2a, κ).CD3 is a heterotetrameric protein consisting of a CD3γ, a CDδ and 2 CD3ε. It forms complex with TCR. OKT-3 recognize human CD3ε. Human CD3 is expressed on the surface of T cells and NKT cells.CD4 is also called Leu-3 or T4. It's a single-chain type I transmembrane glycoprotein, mainly expressed on the surface of T cells, and monocytes/macrophages. In T cells, CD4 forms complex with TCR/CD3 and play important roles in T cell immunity. The target of HIV is CD4+ T cells. Reduction of CD4+ T cells is the main reason of defected immunity after HIV infection.CD8 is mainly expressed on cytotoxic T cells and also some subpopulations of NK cells. CD8 forms dimer function. In most cells, CD8 is a heterodimer consisting of CD8a and CD8b, but in NK cells nearly all CD8 is homodimer of CD8a. CD8a can form co-receptor with MHC-I restricted TCR to promote T cell antigen recognition and activation.无锡市东林科技发展有限责任公司
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入驻年限:10年