APC Anti-Mouse CD51 Antibody

浓度 ：0.2 mg/mL

宿主 ：Rat

适应物种 ：Mouse

保质期 ：12个月

级别 ：科研用

库存 ：大量供应

供应商 ：无锡东林科技

标记物 ：APC

保存条件 ：Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

形态 ：liquid

亚型 ：Rat IgG1, κ

规格 ：20T/100T/200T

CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.