文献支持Recombinant human TNF-α蛋白/Invivogen一级代理商

库存 ：大量

英文名 ：Recombinant human TNF-α

CAS号 ：/

保质期 ：/

供应商 ：欣博盛生物

保存条件 ：-20°C

规格 ：20 µg

产品名称：Recombinant human TNF-a
CHO expressed human tumor necrosis factor alpha with HSA
货号：rcyc-htnfa

产品描述：
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced by several types of cells, predominantly activated macrophages1
. TNF-α plays an important role in the immune response to microbial invasions and in the necrosis of specific tumors. TNF-α binds two receptors TNFR1
and TNFR2 inducing NF-κB and MAPK signaling pathways.
TNF-a exists in two forms; a type II transmembrane protein and a mature soluble protein. The TNF-a transmembrane protein is proteolytically cleaved to yield a soluble protein3
, which subsequently forms a non-covalently linked homotrimer in solution. The individual subunits of this homotrimer have a relative molecular mass each of 17350 Daltons.
Recombinant human TNF-a is intended for use in cell culture applications. Recombinant human TNF-a is produced in Chinese
hamster ovary (CHO) cells transfected with the full-length sequence for the human TNF-a gene. These transfected cells produce and secrete biologically active TNF-a.
1. Sedger L. & McDermott M., 2014. TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future.
Cytokine Growth Factor Rev. 25(4):453-72. 2. Wajant H. et al., 2003. Tumor necrosis factor signaling. Cell Death Differ. 2003 10(1):45-65. 3. Kriegler M. et
al., 1988. Anovel form of TNF/cachectin is a cellsurface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell. 53(1):45-53.

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