p63 (TP63) Mouse Monoclonal Antibody [Clone ID: UMLBI4]

靶点 ：TP63

应用范围 ：WB 1:500, IHC 1:200

宿主 ：Mouse

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

标记物 ：Unconjugated

克隆性 ：Monoclonal Antibody

保存条件 ：Stable for 1 year at -20°C from date of shipment. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

亚型 ：IgG2a

免疫原 ：Full length human recombinant protein of human TP63 (NP_003713) produced in HEK293T cell.

规格 ：100 ug

别名：AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L

产品概述：TP63 mouse monoclonal antibody, clone UMLBI4

总结：This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.