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Integrase-LEDGF/p75 allosteric inhibitor 1
CAS No. : 1431738-14-5
MCE 国际站:Integrase-LEDGF/p75 allosteric inhibitor 1
产品活性:Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) 是一种具有口服活性的 integrase-LEDGF/p75 (IN-LEDGF/p75) 变构抑制剂。Integrase-LEDGF/p75 allosteric inhibitor 1 抑制 HIV-1 DNA 整合,具有抗病毒活性,对 HIV-1重组分子克隆 NL432 的 EC50 为 3.9 nM。
研究领域:Metabolic Enzyme/Protease
作用靶点:HIV Integrase
In Vivo: Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) has moderate metabolic stability (HLM MS = 59%, RLM MS = 61%), exhibits good clearance (CLt = 6.99 mL/min/kg) and good bioavailability (F = 36%) in rats.
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