融合蛋白Recombinant Human SIRPA/mFc Protein

库存 ：999

英文名 ：Human SIRPA/mFc Protein

CAS号 ：/

保质期 ：/

供应商 ：上海百英生物科技有限公司

保存条件 ：This protein can be stored at 2°C to 8°C for 2 weeks under sterile conditions; -20°C for 3 months under sterile conditions; -70°C for 36 months under sterile conditions. Avoid repeated freeze-thaw

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
ALT names: SHPS1;SIRPA;CD172A;BIT;MFR;MYD1;P84;PTPNS1
蛋白纯度：> 95% as determined by SDS-PAGE
蛋白内毒素：<1EU/mg, Determined by LAL gel clotting assay
保存条件：This antibody can be stored at 2°C to 8°C for 2 weeks under sterile conditions; -20°C for 3 months under sterile conditions; -70°C for 36 months under sterile conditions. Avoid repeated freeze-thaw
   百英生物(Biointron)成立于2012年，是一家专注于抗体早期发现CRO服务的行业龙头企业。目前在上海张江和周浦，江苏泰州设有研发和生产中心，在美国和荷兰设有商务中心。公司建有14600多平米符合GMP规范的标准厂房，通过了ISO9001:2015体系认证和两化融合体系贯标，是国家高新技术企业、江苏省潜在独角兽企业、上海市科技小巨人企业。
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