Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt)

保存条件 ：-20

保质期 ：Amyloid-β (Aβ) (17-42) is a 26-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases.{47355} It has been found in postmortem cerebral cortex from patients with Alzhe

英文名 ：Aβ (17-42)|LVFFAEDVGSNKGAIIGLMVGGVVIA

库存 ：500 µg

供应商 ：Cayman

A 26-residue fragment of the Aβ protein; formed via post-translational processing of APP by α- and γ-secretases; has been found in postmortem cerebral cortex from patients with Alzheimer’s disease that have diffuse amyloid plaques and in cerebellar preamyloid lesions in patients with Down’s syndrome; forms amorphous aggregates in vitro that bind less thioflavin T than Aβ (1-40) and Aβ (1-42); is cytotoxic to SH-SY5Y and IMR-32 cells in a concentration-dependent manner and induces cleavage of caspase-3 and PARP in SH-SY5Y cells at 20 μM