Il1f8 (NM_027163) Mouse Recombinant Protein

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

规格 ：20 ug

产品概述：Purified recombinant protein of Mouse interleukin 1 family, member 8 (Il1f8), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug蛋白长度：A DNA sequence from Mouse cDNA ORF Clone, [GM49222V], encoding Mouse full-length Il1f8.表达系统：HEK293T种属：Mouse标签类型：C-MYC/DDK分子量：21.3 kDa通用名：Il1f8总结：Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes.[UniProtKB/Swiss-Prot Function]形式：Liquid浓度：>50 ug/mL as determined by microplate BCA method纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining储存溶液：25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.别名：2310043N20Rik; Il36b