p16INK4A (CDKN2A) Mouse Monoclonal Antibody [Clone ID: LBI8E9]

靶点 ：CDKN2A

浓度 ：1 mg/ml

应用范围 ：WB 1:200 - 1:1000

宿主 ：Mouse

适应物种 ：Human

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

标记物 ：Unconjugated

克隆性 ：Monoclonal Antibody

保存条件 ：Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

亚型 ：IgG1

免疫原 ：Full length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli.

规格 ：100 ul/30 ul

别名：ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4

产品概述：CDKN2A (p16INK4a) mouse monoclonal antibody, clone LBI8E9

总结：This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]