E-Cadherin Rabbit mAb (AMR13177N)

靶点 ：Arc-1; CD324; CDHE; ECAD; LCAM; UVO; CDH1; E-Cadherin

浓度 ：Affinity purification

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

保存条件 ：Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

亚型 ：IgG

免疫原 ：Recombinant protein of human E-Cadherin.

规格 ：50 µl/100 µl/200 µl

分子量：Calculated MW: 90kDa/97kDa
Observed MW: 135KDa

细胞定位：Cell junction, Cell membrane, Endosome, Golgi apparatus, Single-pass type I membrane protein, trans-Golgi network

稀释方法：WB 1:500 - 1:2000

总结：This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.