TPO-R/CD110/c-Mpl Rabbit mAb (AMR13157N)

靶点 ：C-MPL; CD110; MPLV; THCYT2; TPOR

浓度 ：Affinity purification

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

保存条件 ：Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

亚型 ：IgG

免疫原 ：A synthesized peptide derived from human TPO-R/CD110/c-Mpl

规格 ：50 µl/100 µl/200 µl

分子量：Calculated MW: 82kDa
Observed MW: 80KDa

稀释方法：WB 1:500 - 1:2000

总结：In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]