ErbB4/HER4 Rabbit mAb (AMR13128N)

靶点 ：ALS19; HER4; p180erbB4; ERBB4; HER4/ErbB4

浓度 ：Affinity purification

宿主 ：Rabbit

适应物种 ：Mouse, Rat

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

保存条件 ：Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

亚型 ：IgG

免疫原 ：A synthesized peptide derived from human ErbB4/HER4

规格 ：50 µl/100 µl/200 µl

分子量：Calculated MW: 160kDa
Observed MW: 180kDa

细胞定位：Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:2000

总结：This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]