Cyclin D3 Rabbit mAb (AMR12500N)

靶点 ：CCND3; cyclin D3

浓度 ：Affinity purification

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

保存条件 ：Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

亚型 ：IgG

免疫原 ：A synthesized peptide derived from human Cyclin D3

规格 ：50 µl/100 µl/200 µl

分子量：Calculated MW: 32kDa
Observed MW: 33KDa

细胞定位：Cytoplasm, Membrane, Nucleus

稀释方法：WB 1:500 - 1:2000

总结：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]