TRIB2 Rabbit pAb (APR18564N)

靶点 ：TRIB2; C5FW; GS3955; TRB2

浓度 ：Affinity purification

应用范围 ：WB (Mus musculus)

宿主 ：Rabbit

适应物种 ：Human, Mouse

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

保存条件 ：Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

形态 ：形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

亚型 ：IgG

免疫原 ：Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIB2 (NP_067675.1).

规格 ：50 µl/100 µl/200 µl

分子量：Calculated MW: 38kDa
Observed MW: 49kDa

细胞定位：Cytoplasm, cytoskeleton

稀释方法：WB 1:500 - 1:2000

总结：This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.