白介素-23受体抗体价格_品牌:YLKBIO-丁香通官网

供应商：优利科（上海）生命科学有限公司

库存：100

靶点：详询

级别：科研

目录编号：/

克隆性：多克隆

抗原来源：详见说明书

保质期：1年

抗体英文名：Anti-IL-23R

抗体名：IL-23R抗体

标记物：详询

宿主：兔

适应物种：/

免疫原：见产品详情

亚型：IgG

形态：冻干或液体

应用范围：见产品详情

保存条件：-20℃

浓度：1mg/ml

规格：详询

英文名称 Anti-IL-23R

中文名称白介素-23受体抗体

别名 IL-23R; IL23R; interleukin 23 receptor.

浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Dog

产品类型一抗

研究领域免疫学

蛋白分子量 predicted molecular weight: 67kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human IL-23R C-terminus

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Function : Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Subunit : Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.

Subcellular Location : Cell membrane; Single-pass type I membrane protein.

Tissue Specificity : Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Post-translational modifications : Phosphorylated in response to IL23.

DISEASE : Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Similarity : Belongs to the type I cytokine receptor family. Type 2 subfamily.

Contains 2 fibronectin type-III domains.

Database links : UniProtKB/Swiss-Prot: Q5VWK5.3