胰岛素样生长因子结合蛋白4抗体价格

供应商：优利科（上海）生命科学有限公司

库存：55

靶点：详询

级别：科研

目录编号：/

克隆性：多克隆

抗原来源：详见说明书

保质期：1年

抗体英文名：Anti-IGFBP4/IBP4

抗体名：IGFBP4/IBP4抗体

标记物：详询

宿主：兔

适应物种：/

免疫原：见产品详情

亚型：IgG

形态：Lyophilized or Liquid

应用范围：见产品详情

保存条件：-20℃

浓度：1mg/ml

规格：详询

英文名称 Anti-IGFBP4/IBP4

中文名称胰岛素样生长因子结合蛋白4抗体

别名 Insulin-like Growth Factor Binding Protein 4; BP 4; BP4; HT29 IGFBP; IBP 4; IBP4; IGF binding protein 4; IGFBP 4; IBP4_HUMAN.

浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep

产品类型一抗

研究领域肿瘤免疫学生长因子和激素转录调节因子糖尿病

蛋白分子量 predicted molecular weight: 26kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human IGFBP4

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Insulin like growth factor binding protein 4 (IGFBP4) is produced from a DNA sequence encoding the human IGFBP4 protein. Mature human IGFBP4 has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, the recombinant protein migrates as a 32 kDa and 25 kDa protein under reducing and non reducing conditions, respectively. Human IGFBP4 has a potential N-linked glycosylation site and shares approximately 90% amino acid sequence identity with both mouse and rat IGFBP4. IGFBP4 is a member of the superfamily of insulin-like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). IGFBP4 functions as an inhibitor of IGF action and its main function may be to protect cells from overstimulation by IGFs or to allow activation of alternate transmembrane signaling pathways that are inhibited by IGF exposure. IGFBP4 is expressed in multiple tissues including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex.

Function : IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subunit : Binds IGF2 more than IGF1.

Subcellular Location : Secreted.

Similarity : Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Database links : UniProtKB/Swiss-Prot: P22692.2

生长因子和激素（ Growth Factor and Hormones）

IGFBP5胰岛素样生长因子结合蛋白4(IGFBP-4)是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGFBP-4与IGFs结合可以调节IGFs与IGF-I型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用.