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27-TBDMS-4-Dehydrowithaferin A

CAS No. : 1214886-31-3

MCE 国际站：27-TBDMS-4-Dehydrowithaferin A

产品活性：27-TBDMS-4-Dehydrowithaferin A 是一种叶黄素 A 衍生物，对肿瘤细胞具有强大的抗增殖作用。27-TBDMS-4-Dehydrowithaferin A 诱导肿瘤细胞凋亡。27-TBDMS-4-Dehydrowithaferin A 是一种抗癌剂。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: 27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC₅₀=1.7 μM), A-549 (IC₅₀=5.3 μM), MCF-7 (IC₅₀=0.5 μM), and normal Vero cells (IC₅₀=3.1 μM).
27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells.
27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM.

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