英文名 ：ACE-2 (Mammalian,C-Fc)

Recombinant Human ACE-2 (C-Fc)

Catalog #: DRA106      Derived From: Human Cells  

 

Description: 

Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.

Accession:  Q9BYF1

Names(Known as): Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2

 

Quality Control:

Mol Mass: 110.5kDa     AP Mol Mass:  110-140kDa, reducing conditions

Purity: Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity-Elisa:

 

Immobilized 2019-nCoV S Protein RBD-SD1-mFc(Cat#DRA38)at 2μg/ml (100μl/well) can bind Human ACE-2-Fc(Cat#DRA106). The ED50 of Human ACE-2-Fc(Cat#DRA106) is 40.42 ng/ml.

SEC-HPLC:

 

 

 

 

 

Formulation:

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

 

Shipping:

The product is shipped on dry ice pack.

Upon receipt, store it immediately at the temperature listed below.

 

Storage:

Reconstituted protein solution should be stored at  ≤ -20°C.

 

Purification: 
Affinity purification chromatography.

 

IMMUNOREACTIVITY:

Antigen was assessed by binding ability with 2019-nCoV S Protein RBD-SD1-mFc(Cat#DRA38), the ED50 is 25-250 ng/ml.

 

 

Application:
Immunogen, calibrator or standard.

 

Background:

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

 

 

FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY