S-腺苷蛋氨酸脱羧酶抗体

供应商 ：优利科（上海）生命科学有限公司

库存 ：63

靶点 ：/

级别 ：科研

目录编号 ：KT1138

克隆性 ：多克隆

抗原来源 ：/

保质期 ：1年

抗体英文名 ：AMD1/SAMDC

抗体名 ：Rabbit Anti-AMD1/SAMDC antibody

标记物 ：详询

宿主 ：兔

适应物种 ：Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, )

免疫原 ：KLH conjugated synthetic peptide derived from human AMD1/SAMDC: 68-170/334

亚型 ：IgG

形态 ：Liquid

应用范围 ：WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

保存条件 ：-20℃

浓度 ：1mg/ml

规格 ：50ul

中文名称：S-腺苷蛋氨酸脱羧酶抗体

AMD1/SAMDC

别    名：AMD1; S-adenosylmethionine decarboxylase; Adenosylmethionine decarboxylase 1; AdoMetDC; EC 4.1.1.50; FLJ26964; S adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase proenzyme; SamDC.  

分 子 量：38kDa

细胞定位：细胞浆 

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.





产品介绍：该基因的产物是多胺生物合成中重要的中间酶。 多胺精胺、亚精胺和腐胺是细胞增殖和肿瘤促进所必需的低分子量脂肪胺。 该蛋白质跨度为 22 kb，由 9 个外显子和 8 个内含子组成，编码两种 2.1 和 3.4-3.6 kb 的 mRNA，源于使用两种不同的多聚腺苷酸化信号。 原蛋白约为 38.3 kDa，已知其在氨基酸 68 处进行加工以产生 32 和 6 kDa 的两个片段。

Post-translational modifications:
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

注意：
所提供的本产品仅供研究使用，不得用于人类、治疗或诊断应用。