PSD95结合蛋白3抗体

免疫原 ：KLH conjugated synthetic peptide derived from human SAPAP3: 201-300/979

亚型 ：IgG

形态 ：Liquid

保存条件 ：-20℃

克隆性 ：多克隆

标记物 ：详询

适应物种 ：predicted: Human, Mouse, Rat, Dog, Cow, Horse

保质期 ：1年

抗原来源 ：/

目录编号 ：KT0429

级别 ：科研

库存 ：63

供应商 ：优利科（上海）生命科学有限公司

宿主 ：兔

应用范围 ：WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

浓度 ：1mg/ml

靶点 ：/

抗体英文名 ：SAPAP3

抗体名 ：Rabbit Anti-SAPAP3 antibody

规格 ：50ul-200ul

中文名称：PSD95结合蛋白3抗体

英文名称：SAPAP3

别    名：PSD95BP3; DLGAP3; PSD 95/SAP90 binding protein 3; SAP90/PSD 95 associated protein 3; DAP3; Discs, large (Drosophila) homolog associated protein 3; Disks large associated protein 3; DLGAP3; SAPAP 3; DLGP3_HUMAN.  

货号：YLK-KT0429

分 子 量：106kDa

细胞定位：细胞膜 

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.



 

产品介绍：膜相关鸟苷酸激酶 (MAGUK) 蛋白的突触后密度 95 (PSD-95)/SAP90 家族的成员充当多模块支架，在神经元突触处组织蛋白质信号传导复合物。 SAPAP3（PSD-95/SAP90-binding protein 3），也称为 DLGAP3（disks large-associated protein 3）或 DAP3，是一种 979 个氨基酸的蛋白质，属于 PSD-95/SAP90 相关蛋白的 SAPAP 家族。 SAPAP3 定位于细胞连接处以及外周膜和细胞突触，被认为在神经元细胞信号传导和突触的组织中发挥作用，并且还可能作为衔接蛋白发挥作用，可能将离子通道与 细胞骨架。


Function:
SAPAP3, (DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.

注意：
所提供的本产品仅供研究使用，不得用于人类、治疗或诊断应用。