nNOS Antibody

价格：询价

品牌：Cell Signaling Technology 品牌认证

货号：4234

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抗体英文名：nNOS Antibody

抗原：synthetic peptide corresponding to human nNOS

应用范围：W

宿主：Rabbit

供应商：CST

保质期：详见说明书

适应物种：H,M,R

库存：大量

级别：详见MSDS文件

是否单克隆：2

保存条件：-20°c

规格：100 ul (10 western blots)/carrier free & custom formulation / quantity

pathway more info application references datasheet PDF MSDS PDF protocols

Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R	Endogenous	160	Rabbit

Protocols	4234: Western Blotting
Specificity / Sensitivity	nNOS Antibody detects endogenous levels of total nNOS protein.
Source / Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human nNOS. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting Western blot analysis of extracts from mouse and rat brain, using nNOS Antibody.
Background	Nitric Oxide Synthase (NOS) catalyses the formation of nitric oxide (NO) and citruline from L-arginine, oxygen and cofactors. Three family members have been characterized: neuronal NOS (nNOS), which is found primarily in neuronal tissue; inducible NOS (iNOS), which is induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system; and endothelial NOS (eNOS), which is expressed in blood vessels (1). NO is a messenger molecule with diverse functions throughout the body including the maintenance of vascular integrity, homeostasis, synaptic plasticity, long-term potentiation, learning, and memory (2,3). nNOS binds selectively to the second PDZ domain of PSD-95, and the enzymatic activity of nNOS is either downregulated by phosphorylation at Ser847 by CaM-KII or stimulated by calcium influxes governed by the NMDA receptor channels (4-5). Tsutsui, M. (2004) J Atheroscler Thromb 11, 41-48. Son, H. et al. (1996) Cell 87, 1015-10123. Hawkins, R.D. (1996) Neuron 16, 465-467. Watanabe, Y. et al. (2003) Biochem J 372, 465-71. Sears, C.E. et al. (2004) Philos Trans R Soc Lond B Biol Sci 359, 1021-44.
Application References	Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
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