大小鼠ASDI气道高反应检测设备价格_品牌:塔望科技-丁香通官网

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供应商：塔望科技

WBP全身体积描记系统

无约束全身体积描记法（whole-body plethysmograph ，WBP）可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试，避免了创伤性气管切开术及麻醉的影响，使实验过程简便快捷，并适合长期跟踪研究。
实验时，将动物置于密闭体描箱内，体描箱与通向体描箱外的感应器连接。动物呼吸时，其胸廓的起伏使体描箱内容积发生改变，此容积变化通过压力换能器和放大器转换为电信号，经计算机处理后，其呼吸曲线显示于电脑屏幕上，图形经软件处理，可计算出潮气量（TV）、呼气峰流速（PEF）、呼吸频率等呼吸参数。
系统可扩展连接雾化给药器，对体描箱内动物进行雾化给药，过程中呼吸常规指标和气道高反应的变化,用以评价,支气管收缩等。

产品特点

不需要做手术，操作简单
操作简单，可在动物在最自然状态下呼吸的研究以及长期跟踪实验，适合进行药物初筛
具有气溶胶雾化模块
最多同时监测64只动物
具有自动标定功能
具有饮水瓶和食物口，可进行长期连续监测
适用于小鼠、大鼠或其它动物
具有多种功能升级选项，适用不同研究，如低氧干预、脑电监测、呼吸代谢监控等

检测参数

呼吸频率吸气时间松弛时间潮气量呼吸流量累积体积
吸气流量峰值吸气末暂停 Penh 每分通气量呼气时间
呼气流量峰值呼气末暂停每分通气量其它参数

雾化给药:精确、定量

相关扩展应用
1、吸入式毒理

将染毒物质引入动物体积描记器,用于毒理研究

2、低氧研究

可用于低氧或高氧实验

3、呼吸代谢监控、嗅觉行为学

监测吸氧浓度、 CO2浓度、呼吸代谢率，可以用于嗅觉刺激相关的行为学实验

4、光遗传/EEG/电生理集成

可以和光遗传技术、EEG、EMG、电生理等技术联用

5、活动跑轮监测联用

同步监测动物活动量，可增加呼吸代谢监控功能

6、持续注射给药、微透析联用

可实现清醒状态下连续给药、采血、微透析实验

7、同步视频监测

同步的视频录像文件

8、咳嗽检测

通过软件自动监测咳嗽事件

9、各种动物呼吸检测

可定制各种大动物体积描记器，如兔、犬、猴等

10、其它生理指标测量
可在麻醉或清醒状态下测量心电、血压、体温、心率等指标，可与植入式遥测设备联合使用；
如果您有特殊的实验需求，请联系我们具体商谈。

WBP与脑电肌电监测联用
同步监测EEG和EMG波形图、呼吸信号等，可用于监测动物睡眠状态

参考文献
[1]Sun Lingna,Fan Mingrui,Huang Dong,Li Bingqin,Xu Ruoting,Gao Feng,Chen Yanzuo. Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis[J]. Biomaterials,2021(prepublish):

[2]李宁,李红鹏,张本炎,张柳,沈继敏,李庆云.高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制[J].中华医学杂志,2021,101(36):2893-2899.
[3]Xiong Jiaying,Zhuang Tao,Ma Yurong,Xu Junyi,Ye Jiaqi,Ma Ru,Zhang Shuang,Liu Xin,Liu Bi-Feng,Hao Chao,Zhang Guisen,Chen Yin. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain[J]. European Journal of Medicinal Chemistry,2021,226:

型号选择

名称	型号	说明	单位
全身体积描记系统	WBP-4M	四通道，小鼠	套
全身体积描记系统	WBP-4R	四通道，大鼠	套
全身体积描记系统	WBP-4MR	四通道，小鼠+大鼠	套
全身体积描记系统	WBP-8M	八通道，小鼠	套
全身体积描记系统	WBP-8R	八通道，大鼠	套
全身体积描记系统	WBP-8MR	八通道，小鼠+大鼠	套

相关文献

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[2]李宁, 李红鹏, 张本炎, 张柳, 沈继敏, 李庆云. "高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制" [J]. 中华医学杂志, 2021,101(36):2893-2899.

[3]Xiong Jiaying, Zhuang Tao, Ma Yurong, Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao, Zhang Guisen, Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening" [J].Cell Death Dis 13, 559 (2022)

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy" [J].PeerJ 10:e13632

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu, Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages

[15]Zhou J, Chen H, Wang Q, Chen S, Wang, R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, & Jin J. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J]. Aging Cell, 21, e13680.

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