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Binodenoson

CAS No. : 144348-08-3

MCE 国际站：Binodenoson

产品活性：Binodenoson (MRE-0470) 是一种有效且选择性 A2A 腺苷受体激动剂(K_D=270 nM)。Binodenoson 是一种短效冠状动脉扩张剂，作为放射性示踪剂的辅助物，用于心肌负荷显像。

研究领域：GPCR/G Protein

作用靶点：Adenosine Receptor

In Vitro: Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram.

In Vivo: Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage.

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