产品详情
文献和实验
相关推荐
免疫原 :recombinant protein
亚型 :IgG1
形态 :Liquid
克隆性 :Mouse monoclonal Antibody
标记物 :Non-conjugated
适应物种 :Human
库存 :现货
供应商 :华安生物
宿主 :Mouse
应用范围 :WB, ICC
浓度 :2 mg/mL.
规格 :50ul/100ul
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also it acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. It may regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also AMPK phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.攸碧艾(上海)贸易有限公司
实名认证
金牌会员
入驻年限:7年