ERCC8

免疫原 ：KLH conjugated synthetic peptide derived from human ERCC8/CSA 161-260/396

亚型 ：IgG

形态 ：Liquid

克隆性 ：Rabbit polyclonal Antibody

标记物 ：Non-conjugated

适应物种 ：Human, Mouse, Rat, Horse

库存 ：现货

供应商 ：华安生物

宿主 ：Rabbit

应用范围 ：WB, IHC-P

浓度 ：1 mg/mL.

抗体名 ：ERCC8

规格 ：50μl/100μl

Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.