KGP1

免疫原 ：Synthesized peptide derived from part region of human protein

亚型 ：IgG

形态 ：Liquid

克隆性 ：Rabbit polyclonal Antibody

标记物 ：Non-conjugated

适应物种 ：Human, Mouse

库存 ：现货

供应商 ：华安生物

宿主 ：Rabbit

应用范围 ：WB

浓度 ：1 mg/mL.

抗体名 ：KGP1

规格 ：50μl/100μl

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-bindin