ML-SA1

价格： ￥540 - 2800

品牌：MedChemExpress(MCE) 品牌认证

货号：HY-108462

产品详情

ML-SA1

CAS No. : 332382-54-4

MCE 国际站：ML-SA1

产品活性：ML-SA1 作为一种选择性 TRPML 激动剂，通过促进溶酶体的酸化和蛋白酶活性，抑制登格病毒 2 (DENV2) 和寨卡病毒 (ZIKV)。ML-SA1 抗 DENV2 RNA 和 ZIKV RNA 的 IC₅₀ 值分别为 8.3 μM 和 52.99 μM。ML-SA1 诱发自噬。ML-SA1可用于广谱抗病毒研究。

研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Anti-infection

作用靶点：TRP Channel | Flavivirus

In Vitro: ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells.
ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC₅₀ is 8.93 μM. ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC₅₀ value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells.