Biotinylated Human TGF-beta 2 (N-Avi)

英文名 ：Biotinylated Human TGF-beta 2 (N-Avi)

规格 ：20ug/100ug

Biotinylated Human TGF-beta 2 (N-Avi) (CY96)

产品说明(Description)

 

Biotinylated Recombinant Human Transforming Growth Factor Beta-2 is produced by our Mammalian expression system and the target gene encoding Ala303-­Ser414 is expressed with a Avi tag at the N-terminus.

Accession #: P61812

Known as: Transforming growth factor beta-2 proprotein; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; TGFB2

 

制剂(Formulation)

Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

 

质量控制(Quality Control)

 

Purity:        Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.

 

复溶(Reconstitution)

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. 

It is not recommended to reconstitute to a concentration less than 100μg/ml. 

Dissolve the lyophilized protein in 4mM HCl.

Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

保存(Storage)

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. 

Reconstituted protein solution can be stored at 4-7°C for 2-7 days.  

Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

背景(Background)

Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are three isoforms of TGFβ (TGFβ-1, -2 and -3). TGFB2 could be a potential biomarker for screening, surveillance and prognosis in GC, and that TGFB2 might drive EMT in GC through the NGF/TrKs pathway. Overexpression of TGFB2 may drive EMT through the neuriterelated signaling and affect TMB levels by regulating the DNA damage repair pathways and immune infiltrates.TGF-β2 is an immune suppressor involvedin the development of immune tolerance, and recombinant TGF-β2 incubation is more potent than TGF-β1 or TGF-β3 incubation in suppressing macrophage inflammatory responses.

 

电泳(SDS-PAGE)

 

FOR RESEARCH USE ONLY