Recombinant Mouse TfR (N-8His)

价格： ￥600 - 1400

品牌：近岸蛋白(Novoprotein) 品牌认证

货号：CA03

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英文名：Recombinant Mouse TfR (N-8His)

规格：10ug/50ug/500ug/1mg

Recombinant Mouse TfR (N-8His) (CA03)

产品说明(Description)

Recombinant Mouse Transferrin Receptor Protein 1 is produced by our Mammalian expression system and the target gene encoding Cys89-Phe763 is expressed with a 8His tag at the N-terminus.
Accession #: Q62351
Known as: Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD71; Tfrc

制剂（Formulation）
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

质量控制（Quality Control）
Purity:      Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin:   Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

复溶（Reconstitution）
Dissolve the lyophilized protein in distilled water.

保存（Storage）
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.

背景（Background）
Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. It positively regulates T and B cell proliferation through iron uptake.

电泳(SDS-PAGE)

参考文献（Reference）

Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody[J]. Dong Zhang. et al. OncoImmunology. 2020.

FOR RESEARCH USE ONLY