Ugo Basile 大小鼠疼痛甩尾仪，大小鼠甩尾仪价格

库存：100

国食药监械注册号：无

保修期：12个月

现货状态：10天

供应商：玉研仪器公司

据D'Amour&Smith介绍，这种新型甩尾装置用于通过对大鼠尾巴进行热刺激，能够快速精确地筛选镇痛药物而设计，见参考文献。它主要部件由一个强度可调的辐射能I.R.源，通过抛物面反射镜聚焦在鼠尾上。

操作员将大鼠固定在无阻碍的仪表上面板（见图），使其尾部位于嵌入式窗口上，接收I.R.能量。

操作员启动刺激和相关的固态秒计数器。当老鼠感到疼痛并摆动尾巴时，传感器会检测到疼痛，停止秒计数器并关闭灯泡。因此，动物的反应时间被确定并自动记录。

主要主要特点

l 自动检测动物的反应
l 数据可传输到 U 盘或 PC (USB)
l 舒适、无阻碍的工作表面（无突出元件）
l 由于光学元件固定在刚性结构中以及由电子控制的 I.R.流量，因此具有优异的再现性。

仪器描述
仪器部件整齐地排列在一个新设计的盒子里，盒子里包括I.R.源、传感器、微控制器和电子电路。
当计数器停止时，在指示的时间保持冻结显示。延迟时间因此被自动记录。
一个倾斜的小鼠固定器作为可选件提供，配合小鼠一起使用以补偿其将尾巴保持在 45 度向上从而远离热源的趋势。
事实上，具有特定基因消除的小鼠的可用性正在推动从大鼠到小鼠作为研究动物的重大转变。

可选配的小鼠固定器

正在对大鼠进行甩尾测试

控制面板

数据采集
37360 是微处理器控制的单元。存储在其内部存储器中的实验数据可以直接导出到PC USB 或串行端口。
通信由包括在标准配置中的专用CUB数据采集软件包Cat.52050-09管理。
基于 CUB Windows® 的软件包使用户能够将实验数据传送到 PC 并将它们存储到单独的文件中，由市面上大多数统计分析软件进行管理。
37360 配备了一个存储键，用于记录一个或多个会话的所有实验数据，并从远程 PC 对实验布局进行编程。

校准辐射计
每个足底测试装置都通过校准辐射计精确校准。校准辐射计货号 37300。
终端用户应该考虑这个非常有用的可选附件，它使实验者能够：
i) 确保两个或多个装置提供完全相同强度的热伤害性刺激（以 mW/cm2 表示）。
ii) 测量 I.R. 能量（1s 持续时间内的 1mW 对应于 1mJ）的绝对值。

主要技术参数：

参考文献：
The corticosteroid compounds prednisolone and vamorolone do not alter the nociception phenotype and exacerbate liver injury in sickle cell mice LEF Almeida, JM Damsker, S Albani, N Afsar… - Scientific Reports, 2018 (Mice)

Effect of alpha-lipoic acid and its Nano-formulation on streptozotocin induced diabetic neuropathy in Rats P Verma – 2018

β-Endorphin attenuates collagen-induced arthritis partially by inhibiting peripheral pro-inflammatory mediators X He, L Huang, S Qiu, X Yin, Y Shen, Y Wu, Y Jiang… - … and Therapeutic Medicine, 2018

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists R Turnaturi, C Parenti, O Prezzavento, A Marrazzo… - Molecules, 2018

Onosma bracteatum wall: A Potent analgesic agent H Imran, A ur Rahman, T Sohail, SIH Taqvi, Z Yaqeen - Bangladesh Journal of …, 2018

Antinociceptive Effect of Ficus bengalensis Bark Extract in Experimental Models of Pain K Rajdev, S Jain, CH Mahendra, SK Bhattacharaya – 2018

The Roman high-and low-avoidance rats differ in the sensitivity to shock-induced suppression of drinking and to the anxiogenic effect of pentylenetetrazole MG Corda, MA Piludu, F Sanna, G Piras, M Boi… - … Biochemistry and Behavior, 2018

Substituted-quinoxaline-type bridged-piperidin*e compounds as ORL-1 modulators N Tsuno, J Yao - US Patent 9,890,164, 2018

3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system NM dos Santos, NC Pereira, APS de Albuquerque… - Biomedicine & …, 2018

方法学文献：
F.E. D’mour & D.L. Smith: "A Method for Determining Loss of Pain Sensation." J. Pharmacol. Exp. Therap. 72: 74-79, 1941.

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该产品被引用文献

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方法学文献：
F.E. D’mour & D.L. Smith: "A Method for Determining Loss of Pain Sensation." J. Pharmacol. Exp. Therap. 72: 74-79, 1941.