SMIFH2

保存条件 ：-20

保质期 ：SMIFH2 is an inhibitor of formin homology 2 (FH2) domains.{54322} It inhibits assembly of profilin-actin mediated by mouse formin mDia1(FH1FH2) with an IC50 value of approximately 15 μM. It also inhibits actin assembly mediated by FH1FH2 constructs of m

库存 ：1 mg, 10 mg, 5 mg

供应商 ：Cayman

CAS号 ：340316-62-3

An FH2 domain inhibitor; inhibits assembly of profilin-actin mediated by mouse formin mDia1(FH1FH2) (IC50 = ~15 μM); inhibits actin assembly mediated by FH1FH2 constructs of mDia2, C. elegans CYK-1, S. pombe Cdc12 or Fus1, or S. cerevisiae Bni1; disassembles formin-dependent actin cables and contractile rings in fission yeast at 25 μM; cytotoxic to NIH3T3 fibroblasts (IC50 = 28 μM); increases and decreases the percentage of NIH3T3 cells with thin and thick F-actin bundles, respectively, at 10 μM