Cdk4/6 Inhibitor IV

保存条件 ：-20

保质期 ：Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine that reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC50 values of 1.5 and 5.6 μM, respectively.{29264} It demonstrates potent selectivity for Cdk4/6 over Cdk5/p35, v-abl, c-m

英文名 ：CINK4|Cyclin-dependent kinase 4/6 Inhibitor IV

库存 ：1 mg, 10 mg, 5 mg

供应商 ：Cayman

CAS号 ：359886-84-3

规格 ：This biochemical is available in the following size(s) 250 mg, 50 mg, 500 mg - Please inquire

A cell-permeable triaminopyrimidine that selectively and reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity (IC50s = 1.5 and 5.6 μM, respectively); induces cell cycle arrest in the G1 phase and apoptosis in asynchronous cell lines; suppresses tumor growth in mice bearing human HCT116 colon carcinoma xenografts