MRK-560

保存条件 ：-20

保质期 ：MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM).{48318} In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 level

库存 ：1 mg, 5 mg

供应商 ：Cayman

CAS号 ：677772-84-8

A potent inhibitor of γ-secretase (IC50 = 0.65 nM); reduces diethanolamine-soluble Aβ40 levels in APP-YAC transgenic mouse brain from 1-10 mg/kg; reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively); decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer's disease