Montelukast sodium 白三烯拮抗剂和GPR17拮抗剂 151767-02-1

保存条件 ：零下20度

保质期 ：3年

英文名 ：Montelukast sodium

库存 ：大量

供应商 ：上海惠诚生物科技有限公司

CAS号 ：151767-02-1

规格 ：50 mg/250 mg

Montelukast sodium (151767-02-1) is a potent, selective CysLT1 receptor (leukotriene D₄) antagonist (K_i = 0.18 nM).^1,2 Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic asthma.³ Attenuates chronic brain injury after focal cerebral ischemia in rodent models.⁴ Decreases blood brain barrier dysfunction in mouse models.⁵ Blockade of GPR17 by montelukast elevates neural stem and progenitor proliferation.⁶
蒙鲁司特钠(151767-02-1)是一种有效的、选择性的CysLT1受体(白三烯D4)拮抗剂(Ki = 0.18 nM)。 1、2具有抗炎、平喘作用。 治疗慢性哮喘的临床有用药物 减轻鼠模型局灶性脑缺血后慢性脑损伤 降低小鼠模型血脑屏障功能障碍 孟鲁司特阻断GPR17可提高神经干和祖细胞增殖。 

References/Citations:

1) Lynch et al. (1999), Characterization of the human cysteinyl leukotriene CysLT1 receptor; Nature, 399 789
2) Jones et al. (1995), Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist; Can. J. Physiol. Pharmacol., 73 191
3) Reiss et al. (1998), Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group; Arch. Intern. Med., 158 1213
4) Zhao et al. (2011), Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats; J. Pharm. Pharmacol., 63 550
5) Lenz et al. (2014), Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction; Neuroscience, 277 859
6) Huber et al. (2011) Inhibition of leukotriene receptors boosts neural progenitor proliferation; Cell Physiol. Biochem., 28 793

CAS:
151767-02-1
Catalog Number:
10-2597
Activity:
Leukotriene antagonist and GRP17 antagonist
Chemical Name:
2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt
Alternate Names:
MK-0476
Molecular Weight:
608.17
Molecular Formula:
C₃₅H₃₅ClNO₃S
Solubility:
Soluble in DMSO (up to 60 mg/ml), in Water (up to 30 mg/ml) , or in Ethanol (up to 60 mg/ml)
Physical Properties:
Solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
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