Ro 31-8425 HCl PKC PKC抑制剂 145317-11-9

保存条件 ：零下20度

保质期 ：3年

英文名 ：Ro 31-8425 HCl

库存 ：大量

供应商 ：上海惠诚生物科技有限公司

CAS号 ：145317-11-9

规格 ：1 mg/5 mg

Ro 31-8425 (145317-11-9) is a selective, reversible, ATP-competitive inhibitor of protein kinase C. Inhibits PKCα, β1, β2, γ and ε, IC₅₀= 8, 8, 14,13 and 39 nM respectively.¹  Extremely useful tool for probing PKC-dependent physiology² or signaling pathways³. Increases MSC adhesion to an ICAM-1 coated substrate in vitro and enables targeted delivery of systematically administered MSCs to inflamed sites in vivo in a CD11a-dependent manner.⁴  Cell permeable.
Ro 31-8425(145317-11-9)是一种选择性的、可逆的atp竞争蛋白激酶c抑制剂，可抑制PKCα、β1、β2、γ和ε， IC50分别为8、8、14、13和39 nM 这是探测pkc依赖的生理或信号通路的非常有用的工具。 在体外增加间充质干细胞对ICAM-1包被基质的粘附，并能够以cd11a依赖的方式靶向给药间充质干细胞到体内炎症部位 细胞的渗透。

References/Citations:

1) Wilkinson et al. (1993), Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C; Biochem. J., 294 335
2) Niu et al. (2011), PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells; J. Cell Physiol., 226 173
3) Jimenez-Lopez et al. (2005), Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells; J. Pharmacol. Exp. Ther., 312 998
4) Levy et al. (2015), A small-molecule screen for enhanced homing of systemically infused cells; Cell Rep., 10 1261

CAS:
145317-11-9
Catalog Number:
10-1563
Activity:
PKC inhibitor
Chemical Name:
3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrol-2,5-dione hydrochloride
Alternate Names:
BIM X, Bisindolylmaleimide X
Molecular Weight:
460.96
Molecular Formula:
C₂₆H₂₄N₄O₂
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
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