Ferrostatin-1 Ferroptosis inhibitor Ferroptosis抑制剂 347174-05-4

保存条件 ：零下20度

保质期 ：3年

英文名 ：Ferrostatin-1

库存 ：大量

供应商 ：上海惠诚生物科技有限公司

CAS号 ：347174-05-4

规格 ：5 mg/25 mg

Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC₅₀=60 nM), an iron-dependent form of nonapoptotic cell death.¹ Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.¹ Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.² Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models³ and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species⁴.

References/Citations:

1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060
2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732
3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551
4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764

CAS:
347174-05-4
Catalog Number:
10-1380
Activity:
Ferroptosis inhibitor
Chemical Name:
Ethyl 3-amino-4-(cyclohexylamino)benzoate
Molecular Weight:
262.35
Molecular Formula:
C₁₅H₂₂N₂O₂
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT