STF-62247 Autophagy inducer 自噬诱导物 315702-99-9

保存条件 ：零下20度

保质期 ：3年

英文名 ：STF-62247

库存 ：大量

供应商 ：上海惠诚生物科技有限公司

CAS号 ：315702-99-9

规格 ：10 mg/50 mg

STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC₅₀=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable

References/Citations:

1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944
2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987
3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388

CAS:
315702-99-9
Catalog Number:
10-1375
Activity:
Autophagy inducer
Chemical Name:
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
Molecular Weight:
267.35
Molecular Formula:
C₁₅H₁₃N₃S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT