24,25-Epoxycholesterol LXR agonist 24(S)，25-环氧胆固醇 LXR激动剂

保存条件 ：零下20度

保质期 ：3年

英文名 ：24,25-Epoxycholesterol

库存 ：大量

供应商 ：上海惠诚生物科技有限公司

CAS号 ：77058-74-3

规格 ：1 mg/5 mg

24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.¹ Controls cellular cholesterol homeostasis.² 24(S),25-Epoxycholesterol promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells.³ Cell permeable.

References/Citation:

1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126

CAS:77058-74-3
Catalog Number:
10-1330
Activity:
LXR agonist
Molecular Weight:
400.65
Molecular Formula:
C₂₇H₄₄O₂
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT